S. Botox Aesthetic is the just FDA approved medications choice for lateral canthal lines. Botox Cosmetic functions by keeping muscle tissues from tightening so lines and wrinkles are much less prominent sildenafil derivative .D. The studies enrolled 833 adult individuals with moderate to serious lateral canthal lines who had been randomly assigned to get Botox or placebo. Outcomes demonstrated that those treated with Botox acquired greater improvement in comparison to placebo in the looks of lateral canthal lines. The FDA authorized Botox for the treating chronic migraine, serious underarm sweating, blepharospasm and strabismus .